Baculovirus Production
Blue Sky BioServices provides rapid High-Titer Baculovirus Production. We've got the fastest process on Earth (< 15 business days)
Expert Baculovirus Expression Featuring IKM™ Technology
- Multiple parallel process viral stock capacity
- Pharma-grade reagent quality
- Unmatched Speed
- Premium customer service & communication
- Easily combined with cloning or scale-up services
Infection Kinetics Monitoring® (IKM®)
Rudimentary use of baculovirus infection as a tool for protein expression entered the commercial market in kit format during the late 1980s and became a mainstream tool for recombinant protein production in the 1990s. Infection Kinetics Monitoring®, a registered process tool/technology since 2007, was invented at Blue Sky in 2004 as a means to improve upon the efficiency, consistency, and output of the process of baculovirus-mediated protein expression in insect cells. As the name suggests, the platform uses cell monitoring data, and this data is transformed into a smarter analytics for every step of the process.
The process for insect expression historically takes 5–7 weeks from entry plasmid to baculovirus production to bulk infection and expression. Using IKM® Blue Sky has shorted this cycle time to 3–5 weeks. In addition to the time value IKM® extends to clients, the platform obviates the need for cumbersome viral titration, standardizes conditions for enhanced control (lower lot-to-lot variability), and when used for scouting protein output levels can help triangulate the factors necessary for highest output per volume of insect cell culture. Blue Sky has built a veritable “conveyor belt” through its labs around this process and is achieving strong economies that it passes along to clients.
IKM® is unmatched in the marketplace on differentiating factors such as turnaround time and value-added quality. This service is the bedrock for insect expression and probably plays a role in 50–60% of all Blue Sky projects.
