Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme important for generating the lipid signaling molecule lysophosphatidic acid (LPA). Autotaxin has lysophospholipase D activity that converts lysophosphatidylcholine into LPA. Autotaxin functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and as a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids.
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Phosphodiesterase isoform 1A is implicated in fertility, inflammation, and olfaction research.
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Phosphodiesterase isoform 1B is implicated in fertility, inflammation and olfaction research.
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PDE1C is a cGMP-specific cyclic nucleotide phosphodiesterase involved in a calcium-dependent feedback loop regulating insulin release in pancreatic beta cells.
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Phosphodiesterase isoform 3A is implicated in obesity, restenosis, and diabetes research.
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Phosphodiesterase isoform 3B is implicated in obesity, restenosis, and diabetes research.
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Phosphodiesterase isoform 3B is implicated in obesity, restenosis, and diabetes research.
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Phosphodiesterase isoform 3B is implicated in obesity, restenosis, and diabetes research.
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Phosphodiesterase isoform 4B is implicated in airway inflammation, arthritis, learning, stroke, and leukemia research.
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Phosphodiesterase isoform 4C is a homolog of the Drosophila dunce family of genes, which has been implicated in memory and learning. The human enzyme is thought to be a target for antidepressant drugs.
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Phosphodiesterase isoform 4D is a homolog of the Drosophila dunce family of genes, which has been implicated in memory and learning. The human enzyme is thought to be a target for antidepressant drugs.
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Phosphodiesterase isoform 5 is highly expressed in the corpus cavernosum and the retina. It has been made famous by inhibitors which treat erectile dysfunction.
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Phosphodiesterase isoform 5 is highly expressed in the corpus cavernosum and the retina. It has been made famous by inhibitors which treat erectile dysfunction.
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Phosphodiesterase isoform 5 is highly expressed in the corpus cavernosum and the retina. It has been made famous by inhibitors which treat erectile dysfunction. This product is based on the previously crystallized protein domain (PDB: 2H40 and 2H42).
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Phosphodiesterase 6 from bovine retina
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Phosphodiesterase isoform 7A
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Phosphodiesterase isoform 7B
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Phosphodiesterase isoform 8A is implicated in hyperthyroidism and metabolic bone disease research.
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Phosphodiesterase isoform 8B is implicated in hyperthyroidism and metabolic bone disease.
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Phosphodiesterase isoform 9 is a cGMP-specific cyclic nucleotide phosphodiesterase implicated in proper neuronal function.
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Phosphodiesterase isoform 9A is a cGMP-specific cyclic nucleotide phosphodiesterase implicated in proper neuronal function. This product is based on previously crystallized domain PDB 2HD1.
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Phosphodiesterase isoform 10A is implicated in PD, OCD, and additional research
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Phosphodiesterase isoform 10A is implicated in PD, OCD, and additional research
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Phosphodiesterase isoform 11A is implicated in fertility research.
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This product cannot be purchased through the website at this time.
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