AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Deletion of AKT2 in mice leads to an overt diabetic phenotype.

This protein is homologous toamino acid residues N2-E481 of published AKT2 kinase [Homo sapiens] NP_001617. It also has an 8-His-TEV tag on the N terminus. This protein has been co-expressed with PDK1 to increase activation.

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