RedSee™ is a colorimetric tag developed by Blue Sky Biotech to simplify detection of expressed and purified recombinant fusion proteins. This monoclonal antibody (clone 2B3) is suitable for detection and affinity purification.
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RedSee™ is a colorimetric tag developed by Blue Sky Biotech to simplify detection of expressed and purified recombinant fusion proteins. This monoclonal antibody (clone 3E2) is suitable for detection and affinity purification.
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Acid ceramidase is a lysosomal enzyme required to break down ceramide into fatty acids and sphingosine. Mutations in this enzyme have been implicated in Farber disease, a lysosomal storage disorder.
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Acetyl-CoA carboxylase (ACC) is a biotin-dependent enzyme that catalyzes the irreversible carboxylation of acetyl-CoA to produce malonyl-CoA substrate for the biosynthesis of fatty acids through its two catalytic activities, biotin carboxylase (BC) and carboxyltransferase (CT).
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AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake.
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In response to growth factors, receptor tyrosine kinases promote the activation of Akt1 through PI-3-kinase-dependent multi-site phosphoryation by PDK1 and mTOR. The Akt1/PDK1/mTOR SmartScreen™ kit reconstitutes the latter portion of this cascade in a chemically defined system useful in discovery of inhibitors along multiple points within the pathway. Our kit contains HIS-tagged Akt1, HIS- or FLAG- tagged PDK1, FLAG-tagged mTOR (FRAP1), TDA 2.0™, reaction buffers and several peptide substrates. The kit is available in three sizes for assay of 1000, 5000, or 30,000 data points (384-well wells).
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AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. Deletion of AKT2 in mice leads to an overt diabetic phenotype.
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In response to growth factors, receptor tyrosine kinases promote the activation of Akt2 through PI-3-kinase-dependent multi-site phosphoryation by PDK1 and mTOR. The Akt1/PDK1/mTOR SmartScreen™ kit reconstitutes the latter portion of this cascade in a chemically defined system useful in discovery of inhibitors along multiple points within the pathway. Our kit contains HIS-tagged Akt2, HIS- or FLAG- tagged PDK1, FLAG-tagged mTOR (FRAP1), TDA 2.0™, reaction buffers and several peptide substrates. The kit is available in three sizes for assay of 1000, 5000, or 30,000 data points (384-well wells).
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AKT kinases are known to be regulators of cell signaling in response to insulin and growth factors. They are involved in a wide variety of biological processes including cell proliferation, differentiation, apoptosis, tumorigenesis, as well as glycogen synthesis and glucose uptake. AKT3 deficient mice have 25% reduction in brain tissue mass.
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5′ AMP-activated protein kinase (AMPK is a heterotrimeric kinase which is critical for regulation of energy homeostasis.
This enzyme is homologous to Rat AMPK (Alpha-1, Beta-1, Gamma-1).
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A member of the alpha-beta hydrolase family of lipases and peptidases, this protein is phosphorylated in response to insulin stimulation in 3T3L1 adipocytes and in white adipose tissue in mice. AS47 is present in a complex with PDE3b and regulates the level of PDE3b protein in cells.
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Autotaxin, also known as ectonucleotide pyrophosphatase/phosphodiesterase 2 (NPP2 or ENPP2), is a secreted enzyme important for generating the lipid signaling molecule lysophosphatidic acid (LPA). Autotaxin has lysophospholipase D activity that converts lysophosphatidylcholine into LPA. Autotaxin functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and as a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids.
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Mammalian biotin ligase catalyzes the biotination of a lysine in the context of a 66 amino acid acceptor domain.
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Bruton’s tyrosine kinase plays a critical role in B-cell maturation. Mutation of this enzyme is the cause of X-linked agammaglobulinemia (XLA).
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Bruton’s tyrosine kinase plays a critical role in B-cell maturation. Mutation of this enzyme is the cause of X-linked agammaglobulinemia (XLA).
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Bruton’s tyrosine kinase plays a critical role in B-cell maturation. Mutation of this enzyme is the cause of X-linked agammaglobulinemia (XLA).
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Cot/Tpl-2 kinase activation plays a critical role in inflammation through regulation of production of cytokines such as TNF and IL-1β. Elevated levels of these cytokines have been clinically implicated as mediators of a number of autoimmune diseases.
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Cot/Tpl-2 kinase activation plays a critical role in inflammation through regulation of production of cytokines such as TNF and IL-1β. Elevated levels of these cytokines have been clinically implicated as mediators of a number of autoimmune diseases.
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Cot/Tpl-2 kinase activation plays a critical role in inflammation through regulation of production of cytokines such as TNF and IL-1β. Elevated levels of these cytokines have been clinically implicated as mediators of a number of autoimmune diseases.
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Cot/Tpl-2 kinase activation plays a critical role in inflammation through regulation of production of cytokines such as TNF and IL-1β. Elevated levels of these cytokines have been clinically implicated as mediators of a number of autoimmune diseases.
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Cot/Tpl-2 kinase activation plays a critical role in inflammation through regulation of production of cytokines such as TNF and IL-1β. Elevated levels of these cytokines have been clinically implicated as mediators of a number of autoimmune diseases.
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Cot/Tpl-2 kinase activation plays a critical role in inflammation through regulation of production of cytokines such as TNF and IL-1β. Elevated levels of these cytokines have been clinically implicated as mediators of a number of autoimmune diseases.
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The epidermal growth factor receptor (HER-1; EGFR) is a member of the ErbB or epidermal growth factor receptor family. Diminished ErbB signaling has been implicated in diseases such as MS and Alzheimer's syndrome, while aberrant activation may contribute to malignancy of solid tumors.
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V-erb-a erythroblastic leukemia viral oncogene homolog 4 (HER-4) is a member of the ErbB or epidermal growth factor receptor family. Diminished ErbB signaling has been implicated in diseases such as MS and Alzheimer's syndrome, while aberrant activation may contribute to malignancy of solid tumors.
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Fatty acid synthase (FAS) is a multifunctional protein. Its main function is to catalyze the synthesis of palmitate from acetyl-CoA and malonyl-CoA in the presence of NADPH into long-chain saturated fatty acids. FAS is up-regulated in breast cancers and, as well as being an indicator of poor prognosis, may also be worthwhile as a chemotherapeutic target. FAS has also been investigated as a possible oncogene.
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FGF-21 is a potent activator of glucose uptake in adipocytes, protects animals from diet-induced obesity, and lowers blood glucose and triglyceride levels. When therapeutically administered to diabetic rodents it is shown to lower blood glucose and triglyceride levels.
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Glucosylceramide synthase (GCS) catalyzes the transfer of glucose from UDP-glucose to ceramide to form glucosylceramide, the precursor of most higher order glycosphingolipids.
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HCK is a Src-family tyrosine kinase that has been implicated in regulating proliferation, differentiation and migration, and hence an important anti-cancer target.
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HCK is a Src-family tyrosine kinase that has been implicated in regulating proliferation, differentiation and migration, and hence an important anti-cancer target.
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HDAC1 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC1 also interacts with retinoblastoma tumor-suppressor protein; this complex is a key element in the control of cell proliferation and differentiation. Together with metastasis-associated protein-2, it deacetylates p53 and modulates its effect on cell growth and apoptosis.
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HDAC10 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation plays an important role in transcriptional regulation, cell cycle progression, and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. HDAC10 has been shown to interact with Histone deacetylase 2 and Nuclear receptor co-repressor 2.
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Histone deacetylases, such as HDAC11, control DNA expression by modifying the core histone octamers that package DNA into dense chromatin structures and repress gene expression.
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Histone deacetylase 2, also known as HDAC2, belongs to the histone deacetylase family. Histone deacetylases act via the formation of large multiprotein complexes and are responsible for the deacetylation of lysine residues on the N-terminal region of the core histones (H2A, H2B, H3, and H4). This protein also plays an important role in transcriptional regulation, cell cycle progression, and developmental events by associating with many different proteins including YY1, a mammalian zinc-finger transcription factor.
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Histone deacetylase 3 (HDAC3) belongs to the histone deacetylase/AcuC/AphA family. It has histone deacetylase activity and represses transcription when tethered to a promoter. It may participate in the regulation of transcription through its binding with the zinc-finger transcription factor YY1. This protein can also down-regulate p53 function and thus modulate cell growth and apoptosis. This gene is regarded as a potential tumor suppressor gene.
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Histone deacetylase 6 (HDAC6) The protein encoded by this gene belongs to class II of the histone deacetylase/AcuC/AphA family. It contains an internal duplication of two catalytic domains which appear to function independently of each other. This protein possesses histone deacetylase activity and represses transcription.
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Histone deacetylase 8 (HDAC8) belongs to class I of the histone deacetylase/AcuC/AphA family. It has histone deacetylase activity and represses transcription when tethered to a promoter. HDAC8 is responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3, and H4).
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Histone deacetylase 9 (HDAC9) belongs to class I of the histone deacetylase/AcuC/AphA family. It has histone deacetylase activity and represses transcription when tethered to a promoter. HDAC9 may be required for hematopoiesis.
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Hormone sensitive lipase (HSL, LIPE) is stimulated by insulin and promotes the breakdown of triglycerides to free fatty acids.
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Hsp90 (heat shock protein 90) is a molecular chaperone and is one of the most abundant proteins expressed in cells. It is a member of the heat shock protein family which is upregulated in response to stress. Hsp90 plays a Janus-like role in the cell, where it is essential for the creation, maintenance, and destruction of proteins.
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The insulin-like growth factor I receptor (IGF1R) has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. IGF1R plays a critical role in transformation events. IGF1R is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. This protein is His-tagged.
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The insulin-like growth factor I receptor (IGF1R) has a tyrosine-protein kinase activity, which is necessary for the activation of the IGF1-stimulated downstream signaling cascade. IGF1R plays a critical role in transformation events. IGF1R is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. This protein is tandem tagged and includes our proprietary biotinylation motif, the Puritin™ tag, suitable for binding to streptavidin matrices.
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The insulin-like growth factor (IGF) receptor is a paradigm for the growth factor receptor family and is found to be activated in many transformed cell types. Our SmartScreen™ IGF kit contains our His-tagged IGF1R complete intracellular domain RTK enzyme, TDA 2.0™, reaction buffers, and substrate. The kit is available in three sizes for assay of 1000, 5000, or 30,000 data points (384-well wells).
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The insulin receptor (InR) is a transmembrane receptor that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Insulin binds to its receptor which in turn starts many protein activation cascades. These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose, glycogen synthesis, glycolysis, and fatty acid synthesis.
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The insulin receptor (InR) is a transmembrane receptor that is activated by insulin. It belongs to the large class of tyrosine kinase receptors. Insulin binds to its receptor which in turn starts many protein activation cascades. These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose, glycogen synthesis, glycolysis, and fatty acid synthesis.
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The insulin receptor (InR) is a transmembrane receptor that is activated by insulin. It belongs to the large class of receptor tyrosine kinases. Insulin binds to its receptor which in turn starts many protein activation cascades. These include: translocation of Glut-4 transporter to the plasma membrane and influx of glucose, glycogen synthesis, glycolysis, and fatty acid synthesis.
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The insulin receptor is a membrane-associated tyrosine kinase important for glucose metabolism and insulin release through signaling via PI3K and downstream components. It is a highly studied pathway important in metabolic syndrome, particularly obesity and diabetes, as well as some cancers. Our SmartScreen™ insulin receptor kit contains our His-tagged insulin receptor complete intracellular domain RTK enzyme, TDA 2.0™, reaction buffers, and substrate. The kit is available in three sizes for assay of 1000, 5000, or 30000 data points (384-well wells).
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IRS2 associates with the insulin receptor and the IGF1 receptor and serves as an adapter to coordinate a diverse set of downstream effects. Mice lacking IRS2 develop a diabetic phenotype.
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Janus Kinase 2 (JAK2) is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constitutively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis. JAK2 plays a role in leptin signaling and control of body weight.
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